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Research is required to determine the effectiveness of tailored interventions in comparison with other interventions.This review updates a previous Cochrane review (Shaw 2005) of the effects of tailored strategies, which we define as ‘strategies to improve professional practice that are planned taking account of prospectively identified barriers to change’.The effect sizes of these studies varied both across and within studies.Twelve studies provided enough data to be included in the quantitative analysis.These included the effects of: risk of bias, concealment of allocation, rigour of barrier analysis, use of theory, complexity of interventions, and the reported presence of administrative constraints.

We searched the National Research Register to November 2007.

Review content assessed as up-to-date: 14 October 2009.

For this update, in addition to the EPOC Register and pending files, we searched the following databases without language restrictions, from inception until August 2007: MEDLINE, EMBASE, CINAHL, BNI and HMIC.

A meta-regression model was fitted adjusting for baseline odds by fitting it as a covariate, to obtain the pooled odds ratio of 1.54 (95% CI, 1.16 to 2.01) from Bayesian analysis and 1.52 (95% CI, 1.27 to 1.82, P CONTRIBUTIONS OF AUTHORS Richard Baker, Francine Cheater and Elizabeth Shaw were responsible for the planning of the review.

Janette Camosso-Stefinovic was responsible for developing, editing and running search strategies for the review, in collaboration with three successive EPOC Trials Search Coordinators: Jessie Mc Gowan, Doug Salzwedel and Michelle Fiander.

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