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The House of Delegates was modeled after the United States House of Representatives and included representatives from medical organizations across the United States as a formal, reform-minded legislative body.That same year, the Association began a voluntary program of drug approval, which would remain in effect until 1955.The organization was established not only to advance scientific research and improve medical education standards but to improve public health.The AMA established the world's first national code for ethical medical practice, the AMA Code of Medical Ethics.The Supreme Court of the United States upheld Federal Trade Commission order that allowed doctors and dentists to advertise without professional associations interfering in 1982.The order restrained the American Medical Association from obstructing agreements between physicians and health maintenance organizations.

The association called for Congress to take action and campaigned for national reform.Drug companies were required to show proof of the effectiveness of their drugs to advertise them in AMA's journal.In 1906, the American Medical Association established a Physician Masterfile designed to contain data on physicians in the United States as well as graduates of American medical schools and international graduates who are in the United States.The AMA also proposed declaring snuff and chewing tobacco a health hazard, increasing the tax on cigarettes, prohibiting smoking on public transportation and urged medical facilities to ban smoking on their premises.A Federal district judge ruled that the AMA had violated the Sherman Antitrust Act in 1987 by depriving chiropractors access to the Association.

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In 1961, the American Medical Association opposed the King-Anderson bill proposing Medicare legislation and took out advertisements in newspapers, radio and television against government health insurance.